Amgen experimental drug lowers cholesterol in mid-stage trial

LOS ANGELES (Reuters) – Amgen Inc‘s experimental drug AMG145 reduced levels of bad cholesterol by as much as 55 percent in combination with statin drugs in patients genetically predisposed to high cholesterol, according to data from a midstage trial presented on Monday.

The new drug, given by injection every four weeks, is part of a promising new class of biotech medicines known as PCSK9 inhibitors designed to target a protein that prevents the body from removing artery blocking LDL cholesterol from the bloodstream.

Statins, such as Pfizer Inc‘s Lipitor and AstraZeneca’s Crestor, work by preventing the liver from making cholesterol.

The Phase II trial found that after 12 weeks, patients treated with a low dose of AMG145 had a 43 percent reduction in LDL, while those given a higher dose had a drop of 55 percent. Patients treated with a placebo saw a 1 percent increase in LDL cholesterol.

The trial, presented here at the annual scientific meeting of the American Heart Association, included 168 patients with heterozygous familial hypercholesterolemia, in which a defective gene inherited from one parent impairs the ability to properly metabolize LDL. The disorder is estimated to affect about one in 500 people and causes extremely high cholesterol.

The most common side effects seen in the trial were injection-site reactions, cold-like symptoms and headache.

AMG145, along with other PCSK9 inhibitors being developed by companies like Pfizer, Regeneron Pharmaceuticals Inc in partnership with Sanofi and Roche, is a man-made antibody.

(Reporting By Deena Beasley; Editing by Bernard Orr)

Health News Headlines – Yahoo! News

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Sandy could cast doubt on election results

WASHINGTON (Reuters) - The devastating storm that slammed into the U.S. East Coast last week could send winds of uncertainty through Tuesday's presidential election, narrowing an already close contest and casting doubt on the legitimacy of the outcome.

Though superstorm Sandy is unlikely to determine whether President Barack Obama or Republican Mitt Romney wins the White House, experts said it could expose flaws in how the United States conducts elections, leading to protracted legal wrangling and lingering bitterness in a country already fractured along partisan lines.

In a worst-case scenario, the storm disruption could cause Obama to lose the popular vote and still win re-election, stirring up vitriolic memories of the contested 2000 battle that allowed Republican George W. Bush to triumph over Democrat Al Gore.

Last-minute changes imposed by election officials also could

further arm campaign lawyers looking to challenge the result.

At minimum, low turnout would add another wild card to an election projected to be among the closest in U.S. history. Voting could be an afterthought for hundreds of thousands of people still struggling with power outages, fuel shortages and plummeting temperatures.

"It's a possibility that we'll see significant drops in turnout in some of these densely populated areas," said George Mason University professor Michael MacDonald, a voter turnout expert.

"The effects could be quite dramatic in terms of the popular vote," he said.

ONE MORE HEADACHE

Tuesday's election presents yet another headache for local officials in New York and New Jersey, which were hardest hit by the storm. Rescue workers are still recovering bodies, 1.9 million homes and businesses have no power, and tens of thousands of people are without heat as temperatures dip near freezing.

Sandy, one of the most damaging storms to hit the United States, hammered the region with 80-mile-per-hour (129-kph) winds, while walls of water overran seaside communities. At least 113 people in the United States and Canada died.

Election authorities now face unprecedented challenges. In New York City, 143,000 voters have been assigned new polling stations. New York Mayor Michael Bloomberg on Sunday called the city's elections board "dysfunctional" and warned that it needs to clearly communicate changes to poll workers.

In New Jersey, where 25 percent of homes and businesses have no power, officials are allowing displaced voters to cast their ballots by email. In battered Monmouth County, officials are spreading the word about new polling locations in at least 29 towns and setting aside paper ballots to use if electronic voting machines fail.

"Whatever it takes, Asbury Park is voting," City Manager Terence Reidy said.

Legal experts said the late changes, however well-intentioned, may give the losing candidate a basis to challenge results.

"The devil is in the details and no doubt these new rules will be fertile ground for those who choose to challenge the results in the election." said Angelo Genova, a New Jersey election law expert who represents Democratic candidates in this election.

The post-Sandy chaos also could expose flaws in the arcane electoral college system the United States uses to elect presidents.

Candidates are not required to win the popular vote nationwide, but they must amass a majority of the 538 "electoral votes" that are awarded to each state based on population. The system was set up when the United States was founded, as a compromise between slave states and free states.

Usually the electoral college winner also wins the popular vote. But in two elections - 1876 and 2000 - the results diverged, creating historic controversies.

This year, Obama is expected to handily win New York, New Jersey and Connecticut, the states most impacted by the storm. But his popular vote total could fall by hundreds of thousands if large numbers of storm-hit voters in Democratic areas are unable to participate. Conceivably, Obama could win the White House while losing the popular vote.

Several experts said they consider that outcome unlikely.

"You'll see lower turnout, yes, but it's not going to change the outcome of the election," said Hunter College political-science professor Jamie Chandler, who predicts Obama will win by at least 1 million votes.

If Obama carries the popular vote by a narrow margin, it could have implications on his ability to govern effectively, according to Ruy Teixeira, a senior fellow at the liberal Center for American Progress.

"The more Obama has a solid popular margin the better his victory," he said.

On Sunday, several Republicans said the storm gave Obama an advantage in the campaign's final week by shifting public attention away from the sluggish economy and other topics they hoped to emphasize.

"The hurricane is what broke Romney's momentum," former Mississippi Governor Haley Barbour said on CNN.

Obama campaign officials said that they are confident the storm will not interfere with the voting process. But they intend to have legal experts on standby just in case.

"We're going to have lawyers who are ready to make sure people can exercise their right to vote. We're going to protect that as fiercely as we can," Obama senior adviser David Plouffe said on Friday.

(Fixes typo in quote in 14th paragraph) (Additional reporting by Jeff Mason, Erin Smith, Jonathan Spicer, Philip Barbara and Andrew Longstreth; Editing by Marilyn W. Thompson and Paul Simao)

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Brazil’s ‘pop-star priest’ gets mammoth new stage

SAO PAULO (AP) — Brazil‘s “pop-star priest” is already packing in the crowds at the newly opened mammoth sanctuary that he built for his campaign to stem the exodus of faithful from the Roman Catholic Church in Latin America’s biggest nation.

Brazil still has more Catholics than any other country in the world, with about 65 percent of its 192 million people identifying themselves that way in the 2010 census. But that is down from 74 percent in 2000 and is the lowest since records began tracking religion 140 years ago.

That’s where Father Marcelo Rossi‘s Mother of God sanctuary comes in. The not-yet-finished structure will seat 6,000 people and have standing room for 14,000 more, church leaders say. In addition, the grounds outside can hold 80,000 people who could watch Mass on outdoor video screens.

After the inaugural Mass on Friday attracted upward of 50,000 people, a beaming Rossi told reporters: “They couldn’t all fit in. There was a crowd that had to stand outside! That’s a sign we’re on the right path, and it’s this sanctuary.”

Similar numbers jammed into the huge church Saturday.

It’s a fitting stage for Rossi, a Latin Grammy-nominated singer who is known for tossing buckets of holy water on worshippers and performing rollicking Christian songs backed by a blasting live band during Mass.

The church sits on 323,000 square feet (30,000 square meters) of land. Church officials declined to confirm how big the actual building is, though local reports put it at 91,500 square feet (8,500 square meters). That would make it one of the world’s 10 biggest churches. A cross soaring 138 feet (42 meters) into the air is the focal point.

The Mother of God sanctuary is anything but traditional. Designed by noted Brazilian architect Ruy Ohtake, it has a wide-open layout giving it the feel of a warehouse. Concrete walls hold up a sloping blue roof that from the outside looks more like a basketball arena than a house of worship. With the church several years away from completion, white plastic chairs were in the place of pews for a lucky few thousand to grab a seat. The rest had to stand.

Rossi dismisses the idea his huge church is a response to the explosion of the evangelical Christian faith in Brazil. Rather, the priest seems to be battling what recent studies indicate is Catholicism’s biggest enemy: indifference.

While millions of Brazilian Catholics joined Pentecostal congregations in the 1990s, a study conducted last year by Brazil’s Getulio Vargas Foundation based on census data found that the Catholics leaving the church these days are mostly becoming nonreligious. Experts have said the trend of Brazilians deciding organized religion isn’t for them poses a more potent threat to Catholic leaders than losses to the Pentecostals.

Rossi chose to open his new church on the Brazilian holiday of Finados, the nation’s version of the Day of the Dead. “A day, a day that was dead, was transformed!” the priest told worshippers during the service, using his gold-plated microphone.

The “pop-star priest” is seen by Brazilian Catholicism as its biggest weapon against the lack of interest, and his new sanctuary adds to his tools of best-selling books and music recordings to keep worshippers interested in what many complain has become a staid institution.

There was nothing stale about his Mass on Friday.

Singing as loud as they could, waving white hankies and swaying with a rocking band, the 20,000 people who jammed into the Mother of God sanctuary hammed it up for TV cameras and shed tears down their cheeks as their superstar priest waved to them from the pulpit. An estimated 30,000 other people had gathered outside, where young boys climbed up into nearby trees trying to get a glimpse of the church grounds as they squinted over a sea of heads streaming out of the sanctuary.

“We have problems, everyone has problems,” worshipper Zuleima de Oliveira Sales said as she stood in the tightly packed sea of people under the soaring blue roof of the structure, her voice choking. “They don’t come to an end, but I have faith, I have faith in Our Lady.”

That’s the sort of belief the Catholic Church is counting on in Brazil and other developing nations. Leaders from the Vatican on down are looking to them as bulwarks against losses in Europe and the U.S., where sex abuse scandals have inspired many people to leave the church. About half of the world’s Catholics live in Latin America.

Pentecostalism was once seen as a major threat to Brazil’s Catholic Church. Pentecostal churches, many of them founded by U.S. evangelicals, saw their membership double to more than 12 percent of the country’s population over the 1990s, with about half of the congregants estimated to be former Catholics.

During the 1990s, Brazil’s economy suffered from hyperinflation and other woes, and Pentecostal churches aggressively recruited in the slums and poor outskirts of Brazil’s cities by offering nuts-and-bolts self-improvement advice as well as Christian ministry.

Since 2003, however, Pentecostal churches have seen growth slow. The percentage of Brazilians calling themselves Pentecostals edged up from 12.5 percent of the population to 13.3 percent.

Yet the Catholic Church has continued to lose parishioners, and church leaders have had little success so far in halting that trend.

Brazil was the first nation outside Europe that Pope Benedict XVI visited, during a five-day tour in 2007 largely aimed at stopping losses in Latin America. During the trip, the pope canonized Brazil’s first native-born saint.

Then Benedict announced last August during the church’s World Youth Day, which drew 1.5 million people to Spain, that the next version of the gathering would be held in Rio de Janeiro in 2013. The pope is expected to attend.

For now, Rossi hopes his big church will bring together tens of thousands of faithful for every Mass, giving new energy to the Catholic faith.

“People want big spaces. They want grand places for prayer,” he told the Globo TV network. “One candle illuminates, 10 candles illuminate — and 100,000 candles light up so much more.”

Latin America News Headlines – Yahoo! News

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Google's Android software in 3 out of 4 smartphones

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What election? Sandy’s the big story on ‘SNL’

NEW YORK (AP) — You wouldn’t have known it was the Saturday before the election on “Saturday Night Live.”

Sure, Mitt Romney, played by Jason Sudeikis, made a quick appearance on “Weekend Update,” but otherwise much of the focus was on Superstorm Sandy — and Mayor Michael Bloomberg‘s sign-language interpreter, Lydia Callis.

The real Callis has gained some pop-culture popularity with her enthusiastic interpreting of Bloomberg’s words. She was back at the mayor’s side at Saturday’s briefing in New York and was played on “SNL” by Cecily Strong. The mayor — played by Fred Armisen — thanked Callis for bringing “pizazz” to her job.

Hosting Saturday’s show was comedian and TV star Louis C.K. He said in the monologue of New York City: “We’re still standing.”

President Barack Obama didn’t appear on the show.

Entertainment News Headlines – Yahoo! News

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Sanofi considered moving headquarters abroad: report

PARIS (Reuters) – Sanofi‘s management considered moving its headquarters abroad in the last few months but the plan was nixed by the drugmaker’s chairman, French weekly Le Journal du Dimanche reported on Sunday, citing sources close to the board.

First mooted in July, when the Socialist government was preparing to introduce a 75 percent tax on top earnings, the plan envisaged moving the headquarters to London or the United States, or at least relocating Chief Executive Chris Viehbacher and his closest associates abroad.

However, Chairman Serge Weinberg vetoed the project, the newspaper said, saying that Viehbacher had not raised the issue with him.

A Sanofi spokesman denied such plans were discussed and said the company’s recent move to new corporate headquarters in Paris showed its commitment to its base in the city.

Several of the company’s top executives are foreign and spend most of their time travelling abroad.

In addition to German-Canadian Viehbacher, they include Elias Zerhouni, an Algerian-born American in charge of research and development, and Hanspeter Spek, the German-born president of global operations.

Italian Roberto Pucci, senior vice president of human resources, and Karen Linehan, Sanofi’s American-born general counsel, are also part of the executive committee.

Sanofi, which is reshuffling its French research operations at a cost of around 900 jobs, would not be the first French firm to consider moving top executives overseas.

French industrial conglomerate Schneider Electric has kept its headquarters near Paris, but its top managers, including Chief Executive Jean-Pascal Tricoire, relocated to Hong Kong last year in a move to be closer to fast-growing markets in Asia.

Industry Minister Arnaud Montebourg, who has opposed the reorganization of Sanofi’s research activities in France, was cited by the newspaper as saying he hoped the plan was just a rumor.

(Reporting by Elena Berton; Editing by Hugh Lawson)

Health News Headlines – Yahoo! News

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Forget war on women: Men’s vote could decide who wins the White House

A man ponders his vote in Las Vegas. (David Becker/Getty)

A barrage of attention from the presidential candidates and the news media has been paid to "waitress moms," "Walmart women" and other exhibits of the female species this election, with pundits wondering whether the female gender gap, which works in the president's favor, will carry him over the top on Election Day.

But the focus might be better spent on men.

"The issue is not the women's vote, but the men's vote," Frank Newport, Gallup's editor-in-chief, told Yahoo News. The reason: polls show male voters look much more likely to break from their 2008 voting patterns. If that happens, the men's vote could decide whether Barack Obama or Mitt Romney becomes the next president.

Four years ago, Obama won 49 percent of the male vote, buoyed by historic gains with white men, who chose the Democratic candidate in the highest proportions seen since Jimmy Carter. Even so, most white men—57 percent of them—still voted for John McCain, and a majority of such voters have not backed a Democratic candidate since 1964, when men began abandoning the Democratic party.

This year, Obama's inroads with white men have eroded. Worse, the candidate tracks in the low 40s among all men, not just white ones, in the latest ABC/Washington Post polls. It's possible the president will have lost up to 9 points of ground among male voters compared to 2008. No Democratic candidate has been elected in the past 50 years without gaining close to half of the male vote.

Why are some men abandoning Obama? It's open to interpretation, but one fairly straightforward theory from Newport is that male voters rate Romney higher on the issues that they say are most important:  jobs, the economy and the deficit.

Another theory, laid out in a study by Texas A&M political science professor Paul Kellstedt, is that over the past 30 years men have been more likely to shift rightward during economic downturns, supporting conservative candidates who vow to cut back on government spending. Women also shift rightward in response to a faltering economy, but they are more likely than men to support social safety net programs, and thus much less likely to support a candidate who wants government cuts.

On average, men and women think about the role of government in a fundamentally different way, notes the Democratic pollster Celinda Lake. That difference accounts for one of the biggest shifts in party identification in the past 50 years.

Beginning in 1964, but intensifying with Ronald Reagan's first presidential election, men began leaving the Democratic party and voting Republican. The major causes of the shift were attitudes on both government spending and war, according to the Rutgers political scientist Susan Carroll. For the most part women, who in surveys are not only consistently much more wary of government cutbacks than men, but also much less likely to support foreign military interventions and wars, stayed with the Democrats.

It was men, not women, who changed the political landscape by changing their votes, and women who have been the political stalwarts.

It still makes sense, however, for Romney and Obama to make overt appeals to women. (And to give them fervent shout-outs during debates and party conventions.) According to Lake, women make up about 60 percent of undecided voters this election, which is higher than their projected share of the electorate, 52 percent. And in past elections' exit polls, more women than men said they made up their minds about whom to vote for in the last week before an election.

Still, according to the ABC News/Washington Post pollster Gary Langer and other experts, female voters are not expected to change their votes, on average, significantly from 2008, when they were seven percentage points more likely than men to vote for Obama. This is despite a few recent polls suggesting Romney may be closing in on Obama's support with women. (The Obama campaign has been quick to dismiss these polls.)

"I think it's going to end up in that ballpark. I don't expect it will look vastly different," Carroll said of the gender gap.

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Syria army quits base on strategic Aleppo road

BEIRUT (Reuters) – The Syrian army abandoned its last base near the northern town of Saraqeb after a fierce assault by rebels, further isolating the strategically important second city Aleppo from the capital.

But in a political setback to forces battling to topple President Bashar al-Assad, the United Nations said the rebels appeared to have committed a war crime after seizing the base.

The opposition Syrian Observatory for Human Rights said on Friday government troops had retreated from a post northwest of Saraqeb, leaving the town and surrounding areas “completely outside the control of regime forces”.

It was not immediately possible to verify the reported army withdrawal. Authorities restrict journalists’ access in Syria and state media made no reference to Saraqeb.

The pullout followed coordinated rebel attacks on Thursday against three military posts around Saraqeb, 50 km (30 miles) southwest of Aleppo, in which 28 soldiers were killed.

Several were shown in video footage being shot after they had surrendered.

“The allegations are that these were soldiers who were no longer combatants. And therefore, at this point it looks very likely that this is a war crime, another one,” U.N. human rights spokesman Rupert Colville said in Geneva.

“Unfortunately this could be just the latest in a string of documented summary executions by opposition factions as well as by government forces and groups affiliated with them, such as the shabbiha (pro-government militia),” he said.

Video footage of the killings showed rebels berating the captured men, calling them “Assad’s dogs”, before firing round after round into their bodies as they lay on the ground.

Rights groups and the United Nations say rebels and forces loyal to President Bashar al-Assad have committed war crimes during the 19-month-old conflict. It began with protests against Assad and has spiraled into a civil war which has killed 32,000 people and threatens to drag in regional powers.

The mainly Sunni Muslim rebels are supported by Sunni states including Saudi Arabia, Qatar and neighboring Turkey. Shi’ite Iran remains the strongest regional supporter of Assad, who is from the Alawite faith which is an offshoot of Shi’ite Islam.

STRATEGIC BLOW

Saraqeb lies at the meeting point of Syria’s main north-south highway, linking Aleppo with Damascus, and another road connecting Aleppo to the Mediterranean port of Latakia.

With areas of rural Aleppo and border crossings to Turkey already under rebel control, the loss of Saraqeb would leave Aleppo city further cut off from Assad’s Damascus powerbase.

Any convoys using the highways from Damascus or the Mediterranean city of Latakia would be vulnerable to rebel attack. This would force the army to use smaller rural roads or send supplies on a dangerous route from Al-Raqqa in the east, according to the Observatory’s director, Rami Abdelrahman.

In response to the rebels’ territorial gains, Assad has stepped up air strikes against opposition strongholds, launching some of the heaviest raids so far against working class suburbs east of Damascus over the last week.

The bloodshed has continued unabated despite an attempted ceasefire, proposed by join U.N.-Arab League envoy Lakhdar Brahimi to mark last month’s Muslim holiday of Eid al-Adha.

In the latest in a string of fruitless international initiatives, China called on Thursday for a phased, region-by-region ceasefire and the setting up of a transitional governing body – an idea which opposition leaders hope to flesh out at a meeting in Qatar next week.

Veteran opposition leader Riad Seif has proposed a structure bringing together the rebel Free Syrian Army, regional military councils and other rebel forces alongside local civilian bodies and prominent opposition figures.

His plan, called the Syrian National Initiative, calls for four bodies to be established: the Initiative Body, including political groups, local councils, national figures and rebel forces; a Supreme Military Council; a Judicial Committee and a transitional government made up of technocrats.

The initiative has the support of Washington. U.S. Secretary of State Hillary Clinton called on Wednesday for an overhaul of the opposition, saying it was time to move beyond the troubled Syrian National Council.

The SNC has failed to win recognition as the legitimate representative of the Syrian people and Clinton said it was time to bring in “those on the front lines fighting and dying”.

(Additional reporting by Oliver Holmes in Beirut and Stephanie Nebehay in Geneva; Editing by Jon Boyle)

World News Headlines – Yahoo! News

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Google's Android software in 3 out of 4 smartphones

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AP PHOTOS: Stars come out for Sandy victims’ show

NEW YORK (AP) — For the victims of Superstorm Sandy, it was a sorely needed message delivered.

From “Livin’ on a Prayer” to “The Living Proof,” every song Friday at NBC’s benefit concert became a message song.

New Jersey‘s Jon Bon Jovi gave extra meaning to “Who Says You Can’t Go Home.” Billy Joel worked in a reference to Staten Island, the decimated New York City borough.

The hourlong event, hosted by Matt Lauer, was heavy on stars and lyrics identified with New Jersey and the New York metropolitan area, which took the brunt of this week’s deadly storm. The telethon was a mix of music, storm footage and calls for donations from Jon Stewart, Tina Fey, Whoopi Goldberg and others.

The show ended, as it only could, with Bruce Springsteen and the E Street Band, tearing into “Land Of Hope and Dreams.”

“God bless New York,” Springsteen, New Jersey‘s ageless native son, said in conclusion. “God bless the Jersey shore.”

Here, in pictures, are some of the performers on this somber but hopeful night:

Entertainment News Headlines – Yahoo! News

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