Snowstorm triggers deadly Iowa pileup


DES MOINES, Iowa (AP) — The first widespread snowstorm of the season began a slow crawl across the Midwest on Thursday, creating treacherous driving conditions that, in Iowa, led to a 25-vehicle pileup that killed one person.


Drivers were blinded by blowing snow and didn't see vehicles that had slowed or stopped on Interstate 80 about 60 miles north of Des Moines, state police said. A chain reaction of crashes involving semitrailers and passenger cars closed down a section of the highway.


Drivers throughout the Midwest were harried by heavy snow and strong winds that combined for blizzard conditions in areas from Kansas to Wisconsin. Those who planned to fly before the Christmas holiday didn't fare much better. Snow, wind and thunderstorms forced delays and cancellations at some of the nation's busiest airports, including those in Dallas and Chicago. Meanwhile, tens of thousands of people lost power as heavy snow and strong winds pulled down lines.


While the snow had tapered off by sunrise in Des Moines, Iowa transportation officials had advised drivers to stay off highways until midnight, and police repeated that warning after the crash north of the city.


"It's time to listen to warnings and get off the road," said Col. David Garrison, of the Iowa State Patrol. "Iowa's highways and interstates remain in poor condition for travel."


Conditions weren't much better on city streets. Thomas Shubert, a clerk at a store in Gretna near Omaha, said his brother drove him to work in his 4-by-4 truck but that some of his neighbors weren't so fortunate.


"I saw some people in my neighborhood trying to get out. They made it a few feet, and that was about it," Shubert said. "I haven't seen many cars on the road. There are a few brave souls out, but mostly trucks and plows."


The heavy, wet snow made some unplowed streets in Des Moines nearly impossible to navigate in anything other than a four-wheel drive vehicle. Even streets that had been plowed remained snow-packed and slippery. Jackknifed semitrailers were reported on sections of Interstates 80 and 35 east and north of the city, with portions of the roads closed until the accidents could be cleared.


While the snow had tapered off by sunrise in Des Moines, transportation officials warned drivers to stay off highways until midnight. Strong winds were creating whiteout conditions. The airport at Creston, Iowa, recorded the highest winds, with a gust of 53 mph, said Kevin Skow, a National Weather Service meteorologist in the city.


Strong wind contributed to tens of thousands of power outages in Arkansas, Iowa and Nebraska. While snow pulled down most lines in Iowa, others were felled by big gusts, said Justin Foss, a spokesman for Alliant Energy, which had 13,000 customers without power in central Iowa.


"The roads have been so bad our crews have not been able to respond to them," said Justin Foss, a spokesman for Alliant Energy, which had 13,000 customers without power in central Iowa. "We have giant four-wheel-drive trucks with chains on them so when we can't get there it's pretty rough."


Utilities reported more than 33,000 customers without power in the Des Moines area, more than 36,000 outages in eastern Nebraska and more than 41,000 without power in Arkansas, where thunderstorms took out lines. Smaller outages were reported in Alabama, Kansas, Missouri, Illinois and Louisiana.


Meteorologist Scott Dergan said the snow cover would drag temperatures much lower in Nebraska and Iowa.


"We're talking single digits," Dergan said. "We may even see some sub-zero temperatures in Nebraska. This cold weather will stick around for several days, maybe until the day after Christmas. So we're definitely going to have a white Christmas."


Before the storm, several cities in the Midwest had broken records for the number of consecutive days without measurable snow.


Chicago commuters began Thursday with heavy fog and cold, driving rain, and forecasters said snow would hit the Midwestern metropolis by mid-afternoon. Officials at O'Hare International Airport reported some flight delays and more than 90 cancellations. United Airlines said it would waive change fees for travelers who have to change their plans for travel through O'Hare because of the storm.


American Airlines reported 120 cancellations in Dallas because of thunderstorms there. There also were delays, most involving smaller regional planes that have more flight restrictions, spokeswoman Andrea Huguely said.


"We are trying to delay as much as we can, instead of canceling, because we know that we have many customers who are trying to make their holiday travel plans," Huguely said.


Along with Thursday's fatal accident in Iowa, the storm that swept through the Rockies earlier in the week was blamed for deaths in Wisconsin and Utah. At least two people died Wednesday in a fatal crash on slick roads in southeastern Wisconsin, sheriff's officials said. In southeastern Utah, a woman who tried to walk for help after her car became stuck in snow died Tuesday night. Search and rescue crews on snowmobiles found her buried in the snow just a few miles from her car.


The owner of the Norske Nook restaurant and bakery in Osseo, a town in west-central Wisconsin that woke up to at least 10 inches of snow, said "blizzardy" conditions were not unusual for the area and that the weather would not upset her business.


"It's our policy to stay open for the customers," said Jean Zingshiem. "In case someone is stranded they'll have somewhere to go."


Bill Riggins, of Madison, Wis. said he wouldn't let a little blizzard stop him from riding his bike into work on the University of Wisconsin campus, about five miles from his house. Riggins said his metal-studded snow tires did the trick for the early morning commute at 4:45 a.m.


"I honestly think it would have been more trouble to drive," Riggins said. The ride, which normally takes about 25 minutes, took 40 in the snow. As conditions worsen during the day, Riggins said he expected the ride home to take about an hour.


On the southern edge of the storm system, high winds damaged homes and downed trees in central Arkansas, the weather service said. A powerful storm peeled the roofs off buildings and toppled trucks in Mobile, Ala., but injured no one. Tornado warnings remained in effect in parts of Mississippi, Louisiana and Alabama early Thursday.


Hundreds of schools across the Midwest canceled classes Thursday because of heavy overnight snow. Government offices in Iowa and Nebraska were closed.


The moisture was welcome to farmers in the drought-parched region, but Meteorologist Kris Sanders said the storm wouldn't make much of a dent. In Kansas, for example, some areas are more than 12 inches below normal precipitation for the year.


"It's not going to have a big effect, maybe only a half-inch of liquid precipitation. It's not helping us out much," Sanders said.


Sanders said another storm similar to the current one could bring additional snow on Christmas or the day after.


Blake Landau, a cook serving eggs, roast beef sandwiches and chili to hungry snow plow drivers at Newton's Paradise Cafe in downtown Waterloo, Iowa, said he has always liked it when it snows on his birthday. He turned 27 on Thursday.


"It's kind of one of those things where it's leading up to Christmas time," Landau said. "We don't know when we get our first snowfall, and I hope we get it by my birthday. It's nice to have a nice snowy Christmas."


___


Beck reported from Omaha, Neb. Associated Press writers Scott Mayerowitz in New York; Dinesh Ramde and Gretchen Ehlke in Milwaukee; Scott Bauer in Madison, Wis.; Heather Hollingsworth in Kansas City, Mo.; Carla K. Johnson and Jason Keyser in Chicago; Jill Bleed in Little Rock, Ark.; and Ryan J. Foley in Iowa City, Iowa contributed to this report.


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Wii U finally gets Nintendo’s TVii service on December 20th






After a month-long delay, Nintendo (NTDOY) will launch its Nintendo TVii service for the Wii U on December 20th in the U.S. and Canada. Nintendo TVii is the company’s take on organizing all of the various video streaming and DVR services a user might subscribe to and then displaying them in an easy-to-navigate touchscreen-based interface on the Wii U GamePad. With Nintendo TVii, Nintendo hopes to make content discovery an easier task, rather than a chore. At the same time, Nintendo TVii will offer new “second-screen” experiences (similar to Xbox SmartGlass) with built-in social sharing options to Facebook (FB), Twitter and the Wii U console’s Miiverse.


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Nintendo TVii will support Amazon (AMZN) Instant Video, Hulu Plus and cable and satellite providers on Thursday, but Netflix (NFLX) and TiVo (TIVO) support won’t hit the U.S. until “early 2013.” Nintendo didn’t state when TVii support for the latter two will hit Canada.


For the consumer’s sake, we hope the download for Nintendo TVii doesn’t take as long as past system updates.


Nintendo’s press release follows below.



Nintendo Makes TV Smart and Social – Nintendo TVii Launches Dec. 20


New Wii U Service Gives Every Member of the Family His or Her Own Personalized, Easy-to-Use Second-Screen Viewing Experience


REDMOND, Wash.–(BUSINESS WIRE)–The company that changed how we play is about to change how we watch. On Dec. 20, Nintendo will introduce Nintendo TVii, a free, integrated service for the recently launched Wii U console that combines what you watch and how you watch into one seamless, second-screen experience on the revolutionary new Wii U GamePad controller.


The rapid increase in both the quality and availability of video entertainment content – hundreds of satellite and cable channels, a seemingly endless amount of video-on-demand options – has made finding something to watch a complex and occasionally frustrating process. The solution to this problem is coming from perhaps an unexpected place: a video game console.


“After Dec. 20, you’ll never look at your TV the same way again,” said Nintendo of America President and COO Reggie Fils-Aime. “Wii U owners have already experienced the transformative effect that the GamePad has on game play and social interaction. Nintendo TVii shows how the integrated second screen of the GamePad can also transform and enhance the TV viewing experience. Welcome to the new world of TVii.”


Nintendo TVii maximizes Wii U owners’ current cable, satellite and video-on-demand services by pulling all of their available content sources – such as a Comcast cable package or Hulu Plus subscription – into one place. This empowers Wii U owners to focus on whatthey want to watch and not how they want to watch. And once users find the show, sporting event or movie they want, they press an icon and Nintendo TVii does the rest.


In addition to greatly simplifying finding and watching video content, Nintendo TVii also includes a series of social features that enable Wii U owners to share experiences and exciting moments with friends as they are happening on live TV. People can engage with others by commenting and sharing on Miiverse, Facebook and Twitter. Or they can comment, post or tweet about an incredible touchdown, a remarkable performance or a shocking plot twist, all using the personal screen of the Wii U GamePad.


Nintendo TVii requires no additional equipment and can be enjoyed with very little setup, demonstrating what’s possible when the second screen is truly integrated with the TV. Wii U owners can also discover more information about what they’re watching by easily accessing information on the GamePad via an Internet connection, including cast details, movie reviews from Rotten Tomatoes and sports data such as live stats and scores.


Nintendo TVii launches in the United States and Canada on Dec. 20. At launch, the service will support cable and satellite providers in both regions, as well as direct integration with Amazon Instant Video and Hulu Plus subscriptions in the United States. Further integration with Netflix subscriptions and TiVo are expected in early 2013 in the United States. Wii U owners with a Netflix subscription can still access the Netflix application from the Wii U system’s main menu and enjoy their favorite content accordingly.


All elements of the Nintendo TVii service are included in the purchase price of the Wii U system. Users will define which services they currently subscribe to – including the channel lineup in their cable package and video-on-demand service subscriptions – as part of the setup process.


Nintendo TVii observes the Wii U system parental controls, and additional options specific to the Nintendo TVii features can be chosen in the Nintendo TVii settings. Every member of the family can create a different viewing profile. For more information about this and other features, visit http://www.nintendo.com/wiiu.



This article was originally published by BGR


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Madonna leads Billboard’s top-grossing tours






LOS ANGELES (Reuters) – While this year’s pop charts have been dominated by young singers, it is veteran music stars, led by Madonna, who are commanding big money in tour ticket sales, according to a new Billboard list released on Tuesday.


Madonna, 54, topped Billboard‘s list of highest-grossing live tours, earning an estimated $ 228.4 million in ticket sales from her sold-out ninth worldwide tour in support of her 12th studio album “MDNA.” The singer will wrap her tour in South America this weekend, after performing more than 80 shows across the world starting in Israel in May.






Madonna came ahead of pop star Lady Gaga, who landed at No. 6, with ticket sales of $ 124.9 million from her worldwide “Born This Way Ball” tour. Gaga, 26, is currently midway through her tour, which kicked off in South Korea in April, and will wrap in Oklahoma in March 2013.


Music publication Billboard compiled its list through estimated gross ticket sales figures from Billboard box scores, which tracks concert tours, ticket prices and sales.


The top five highest-grossing tour acts of 2012 included Bruce Springsteen, 63, and the E Street band at No. 2 with $ 199 million from 72 shows and Pink Floyd’s Roger Waters, 69, at No. 3 with $ 186 million.


Cirque Du Soleil‘s homage to late singer Michael Jackson in “The Immortal World Tour” ranked No. 4 with $ 147.3 million over 183 shows, and British rock band Coldplay was fifth with $ 147.2 million over 67 shows.


The only other young stars in the list of 25 top-grossing tours was Canadian pop star Justin Bieber, 18, at No. 20 with $ 30 million from 29 shows as part of his ongoing “Believe” tour, and country-pop darling Taylor Swift, 23, who raked in $ 26 million from 21 shows from her “Speak Now World Tour.”


Last year, Swift ranked No. 5 on Billboard‘s list with an estimated $ 97 million in ticket sales from her “Speak Now World Tour,” while Bieber came in at No. 15 with $ 44 million.


Swift will embark on her third worldwide concert tour in support of her studio album “Red” in March 2013.


(Reporting By Piya Sinha-Roy; Editing by Patricia Reaney and Eric Walsh)


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Drugs group Lundbeck’s shares hit by profit warning






COPENHAGEN (Reuters) – Shares in Danish drugs firm Lundbeck fell to their lowest level in over 12 years on Wednesday after it cut its profits forecast for the next two years as European sales slow and spending on new products rise to combat generic competition.


The company has already warned that earnings would stall until 2015 due to cheap generic competition for its existing drugs, meaning new products will be vital for future earnings.






But Chief Executive Ulf Wiinberg said on Wednesday that the negative impact on revenue from healthcare reforms in Europe had also been bigger than expected in the last two years and that slowing European sales and generic competition were hurting.


As a result the company said operating profits would fall further than previously forecast in 2014 as it increases investments in its late-stage drugs development pipeline and product launches.


Lundbeck is working to find new drugs to replace lost revenue from products coming off patent protection such as its antidepressant Cipralex, which is sold as Lexapro in the United States and Japan, and Alzheimer’s drug Ebixa.


Wiinberg said 2014 would be the company’s peak investment year for the new products pipeline, offering it a solid foundation for growth starting in 2015.


“You only get one chance to launch a product and we have to do it well,” Wiinberg said at a briefing for investors.


He was commenting after the company warned in a statement that it now expects revenue in 2014 of about 14 billion Danish crowns ($ 2.5 billion) and an operating profit of between just 0.5 billion and 1 billion crowns.


Analysts have on average been forecasting a profit of over 2.5 billion crowns for 2014 on turnover of over 14.7 billion crowns, according to Thomson Reuters I/B/E/S Estimates.


Two years ago Lundbeck predicted its annual revenues over the period 2012-2014 would exceed 14 billion crowns a year while earnings before interest and tax (EBIT) would exceed 2 billion crowns a year.


Next years’ revenue is now forecast to be in the range of 14.1 billion and 14.7 billion crowns to produce an operating profit of 1.6 billion to 2.1 billion crowns, with no change to the company’s forecast for 2012.


Analysts’ forecasts for this year are for operating profit to drop 41 percent to 1.99 billion crowns on revenue down 8 percent at 14.7 billion crowns, while for 2013 they predict a profit of 2.26 billion crowns on revenue of 14.5 billion crowns.


Lundbeck’s shares were trading down 17 percent at 79.90 crowns at 12.44 p.m. British time, dropping below 80 crowns for the first time since April 2000.


“In the short term, earnings are under pressure,” Sydbank analyst Soren Hansen said.


Lundbeck said that it expects a dividend payout ratio of about 35 percent of net profits in the 2012-14 period. Last year it paid 3.49 crowns on basic earnings per share of 11.64 crowns, a payout ratio of 30 percent.


Analysts have been predicting a 27-30 percent cut this year to 2.53-2.28 crowns, according to Thomson Reuters StarMine data.


But a number of analysts doubt that revenue from new products will be enough to secure revenue growth in 2015, compensating for lost revenue from Cipralex, Lexapro and Ebixa which together accounted for about 70 percent of group revenue in 2011.


Lundbeck is working on new products such as antidepressant Brintellix in Europe and the United States for launch at the end of next year or start of 2014, as well as alcohol dependency treatment Selincro in Europe in mid 2013.


“It is difficult to see revenue from the smaller products compensating for the large products,” said Hansen.


“They have a lot of new products in the portfolio and a lot of products in the pipeline, but revenue growth in 2015 is not very likely,” he said. ($ 1=5.6458 Danish crowns)


(Editing by Greg Mahlich)


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Obama sets Jan. deadline for proposals to curb gun violence


WASHINGTON (AP) — Spurred by a horrific elementary school shooting, President Barack Obama tasked his administration Wednesday with creating concrete proposals to reduce gun violence that has plagued the country.


"This time, the words need to lead to action," said Obama, who set a January deadline for the recommendations. He vowed to push for their implementation without delay.


The president, who exerted little political capital on gun control during his first term, also pressed Congress to reinstate an assault weapons ban, which expired in 2004. He also called for stricter background checks for people who seek to purchase weapons and limited high capacity clips.


"The fact that this problem is complex can no longer be an excuse for doing nothing," Obama said. "The fact that we can't prevent every act of violence doesn't mean we can't steadily reduce the violence."


Obama's announcement Wednesday underscores the urgency the White House sees in formulating a response to the shooting in Newtown, Conn. Twenty children and six adults were killed when a man carrying a military-style rifle stormed an elementary school.


The massacre has prompted several congressional gun rights supporters to consider new legislation to control firearms, and there is some concern that their willingness to engage could fade as the shock and sorrow over the Newtown shooting eases.


Obama said Wednesday it was "encouraging" to see people of different backgrounds and political affiliations coming to an understanding that the country has an obligation to prevent such violence.


Appealing to gun owners, Obama said he believes in the Second Amendment and the country's strong tradition of gun ownership. And he said "the vast majority of gun owners in America are responsible."


The president tasked Vice President Joe Biden with leading the administration-wide effort to create new gun control policies. Obama also wants his team to consider ways to improve mental health resources and address ways to create a culture that doesn't promote violence.


The departments of Justice, Education, Health and Human Services, and Homeland Security will all be part of the process.


Biden's prominent role in the process could be an asset for the White House in getting gun legislation through Congress. The vice president spent decades in the Senate and has been called on by Obama before to use his long-standing relationships with lawmakers to build support for White House measures.


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Syrian rebels take control of Damascus Palestinian camp






BEIRUT (Reuters) – Syrian rebels took full control of the Yarmouk Palestinian refugee camp on Monday after fighting raged for days in the district on the southern edge of President Bashar al-Assad‘s Damascus powerbase, rebel and Palestinian sources said.


The battle had pitted rebels, backed by some Palestinians, against Palestinian fighters of the pro-Assad Popular Front for the Liberation of Palestine-General Command (PFLP-GC). Many PFLP-GC fighters defected to the rebel side and their leader Ahmed Jibril left the camp two days ago, rebel sources said.






“All of the camp is under the control of the (rebel) Free Syrian Army,” said a Palestinian activist in Yarmouk. He said clashes had stopped and the remaining PFLP fighters retreated to join Assad‘s forces massed on the northern edge of the camp.


The battle in Yarmouk is one of a series of conflicts on the southern fringes of Assad’s capital, as rebels try to choke the power of the 47-year-old leader after a 21-month-old uprising in which 40,000 people have been killed.


Government forces have used jets and artillery to try to dislodge the fighters but the violence has crept into the heart of the city and activists say rebels overran three army stations in a new offensive in the central province of Hama on Monday.


On the border with Lebanon, hundreds of Palestinian families fled across the frontier following the weekend violence in Yarmouk, a Reuters witness said.


Syria hosts half a million Palestinian refugees, most living in Yarmouk, descendants of those admitted after the creation of Israel in 1948, and has always cast itself as a champion of the Palestinian struggle, sponsoring several guerrilla factions.


Both Assad’s government and the mainly Sunni Muslim Syrian rebels have enlisted and armed divided Palestinian factions as the uprising has developed into a civil war.


“NEITHER SIDE CAN WIN”


Syrian Vice President Farouq al-Sharaa said in a newspaper interview published on Monday that neither Assad’s forces nor rebels seeking to overthrow him can win the war.


Sharaa, a Sunni Muslim in a power structure dominated by Assad’s Alawite minority, has rarely been seen since the revolt erupted in March 2011 and is not part of the president’s inner circle directing the fight against Sunni rebels. But he is the most prominent figure to say in public that Assad will not win.


Sharaa said the situation in Syria was deteriorating and a “historic settlement” was needed to end the conflict, involving regional powers and the U.N. Security Council and the formation of a national unity government “with broad powers”.


“With every passing day the political and military solutions are becoming more distant. We should be in a position defending the existence of Syria. We are not in a battle for an individual or a regime,” Sharaa was quoted as telling Al-Akhbar newspaper.


“The opposition cannot decisively settle the battle and what the security forces and army units are doing will not achieve a decisive settlement,” he said, adding that insurgents fighting to topple Syria’s leadership could plunge it into “anarchy and an unending spiral of violence”.


Sources close to the Syrian government say Sharaa had pushed for dialogue with the opposition and objected to the military response to an uprising that began peacefully.


In a veiled criticism of the crackdown, he said there was a difference between the state’s duty to provide security to its citizens, and “pursuing a security solution to the crisis”.


He said even Assad could not be certain where events in Syria were leading, but that anyone who met him would hear that “this is a long struggle…and he does not hide his desire to settle matters militarily to reach a final solution.”


In Hama province, rebels and the army clashed in a new campaign launched on Sunday by rebels to block off the country’s north, activists said.


The Syrian Observatory for Human Rights, an opposition-linked violence monitor, said fighting raged through the provincial towns of Karnaz, Kafar Weeta, Halfayeh and Mahardeh.


It said there were no clashes reported in Hama city, which lies on the main north-south highway connecting the capital with Aleppo, Syria’s second city.


Qassem Saadeddine, a member of the newly established rebel military command, said on Sunday fighters had been ordered to surround and attack army positions across the province. He said Assad’s forces were given 48 hours to surrender or be killed.


In 1982 Hafez al-Assad, father of the current ruler, crushed an uprising in Hama city, killing up to 30,000 civilians.


Qatiba al-Naasan, a rebel from Hama, said the offensive would bring retaliatory air strikes from the government but that the situation is “already getting miserable”.


(Additional reporting by Oliver Holmes, Erika Solomon and Dominic Evans in Beirut, Afif Diab at Masnaa, Lebanon; editing by Philippa Fletcher)


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EU’s Almunia sets deadline for Google antitrust plan






BRUSSELS (Reuters) – The European Union set Google an ultimatum on Tuesday, giving it a month to come up with detailed proposals to resolve a two-year investigation into complaints that it used its power to block rivals, including Microsoft.


The EU’s antitrust chief, Joaquin Almunia, delivered the deadline in a meeting with Google Executive Chairman Eric Schmidt in Brussels.






If it fails to address the complaints, the world’s most popular search engine could face a lengthy battle with what is arguably the world’s most powerful antitrust authority. If found guilty, it could mean a fine of up to 10 percent of its revenue, or $ 4 billion.


“Since our preliminary talks with Google started in July, we have substantially reduced our differences regarding possible ways to address each of the four competition concerns expressed by the Commission,” Almunia said in a statement.


“On the basis of the progress made, I now expect Google to come forward with a detailed commitment text in January 2013.”


Almunia said he would seek feedback from rivals and users once he has received Google’s proposal.


Google said it continues to work co-operatively with the Commission.


The European Commission has been examining informal settlement proposals from Google since July but has not sought feedback from the complainants, suggesting it is not convinced by what Google has put on the table so far.


The EU watchdog’s two-year investigation has centered on complaints that Google unfairly favored its services over its rivals in search results, and that it may have copied material from travel and restaurant websites without permission.


The Commission is also looking into whether Google restricted advertisers from transferring their data to rivals.


The Commission’s decision to press Google to offer more far-reaching concessions comes in sharp contrast to the case U.S. regulators have against the company.


Sources told Reuters the U.S. Federal Trade Commission could drop their investigation into Google without requiring any major change in how the company does business.


(Reporting by Foo Yun Chee; Editing by Robin Emmott, Louise Heavens and Nick Zieminski)


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Ben Stiller’s Red Hour sells two more comedies to ABC Studios






LOS ANGELES (TheWrap.com) – Ben Stiller‘s Red Hour Television is continuing to pump out comedies for ABC Studios.


Following the sale of “Complikated” in October, the production company has sold network’s production division two new series – “You’re Not Doing It Right” and “Between Two Kings” – a rep for Red Hour told TheWrap on Monday.






Comedian Michael Ian Black writes, stars and produces in the former, a half-hour single-camera comedy based on his book of the same name that explores his childhood, marriage, children and career. Set “in the wilds of Connecticut,” the show takes a hard look at what happens when you wake up, look around and don’t recognize the life you’re living as your own, Red Hour said.


“Between Two Kings” is written and executive-produced by Jeff Kahn, who has written for series like “Drawn Together” and “The Ben Stiller Show.” It follows the hardships of a divorced father raising an 11-year-old son while living in his elderly father’s home.


Both are being executive-produced by Stiller, along with Red Hour’s Debbie Liebling and Stuart Cornfeld.


Since signing an overall deal with ABC Studios at the end of 2011, Red Hour also has sold “Please Knock,” written by Kevin Napier, and “The Notorious Mollie Flowers,” written by Adam Resnick.


The sale of “You’re Not Doing It Right” and “Between Two Kings” were first reported by Deadline.


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Merck, GE to collaborate on Alzheimer’s drug development






(Reuters) – Merck & Co and General Electric Co‘s healthcare unit have agreed to collaborate on an experimental drug for Alzheimer’s disease, the companies said on Tuesday.


GE Healthcare will supply Flutemetamol, an investigational imaging agent, to Merck for use with its experimental Alzheimer’s disease drug MK-8931.






The companies hope GE’s imaging agent will help identify patients who might benefit from a therapy such as Merck’s, which targets beta amyloid, a protein that can clump together and form plaques in the brain. Such plaques have been found in the brains of patients with Alzheimer’s disease.


MK-8931 is Merck’s lead Alzheimer’s drug candidate and is designed to modify progression of the disease as well as improve symptoms. Alzheimer’s robs patients of their memory and can cause other cognitive disturbances.


Based on promising results from an early-stage clinical trial of MK-8931, Merck plans to move forward with a larger trial, called EPOCH, at multiple sites around the world.


Flutemetamol is a positron emission tomography (PET) imaging agent that has been able, in clinical trials, to detect beta amyloid in the brain.


GE Healthcare will supply Flutemetamol to help select patients for clinical trials and evaluate the agent as a companion diagnostic tool. Financial and other terms of the agreement between the companies were not disclosed.


(Reporting By Toni Clarke; editing by John Wallace)


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Live chat: Newtown rebuilds after shooting

In the aftermath of Friday's Newtown school shooting, we've heard tales mostly horrifying and occasionally heroic, from surviving witnesses and mourning citizens alike, but this one lies somewhere in between, all the more unshakeable. One six-year-old Sandy Hook student played dead in her first-grade classroom, her family pastor said late Sunday, with the kind of quick thinking that ended up saving her life but now leaves her with the unshakeable memories of watching all her classmates being shot and killed. ...
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